Michael W. Schwartz

Central Glucagon-Like Peptide-1 Agonism Ameliorates Colonic Inflammation in a Murine Model of Inflammatory Bowel Disease

This study shows that central GLP-1 receptor activation reduces colonic inflammation in a mouse model of IBD, independent of peripheral effects.

AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose

The paper investigates the two-phase response of AgRP neurons to oral glucose and finds that the second phase tracks glycemic response and aligns with blood glucose rate of change.

A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity

Sex differences in GLP-1 signaling across species

The paper investigates sex differences in GLP-1 receptor agonist side effects using EMR data and in vivo assays, finding higher nausea rates in women and estrous cycle-related variations in mice.

Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1

This study shows that sustained hypothalamic MAPK/ERK signaling is essential for FGF1-induced diabetes remission in rodents.

Cold-induced hyperphagia requires AgRP-neuron activation in mice

The paper shows that AgRP-neuron activation is required for cold-induced hyperphagia in mice.

Leptin-receptor neurons in the dorsomedial hypothalamus regulate the timing of circadian rhythms in feeding and metabolism in mice

This study identifies DMH leptin receptor-expressing neurons as critical for regulating circadian rhythms in feeding and metabolism in mice.