Tongyin Zheng

This study uses NMR spectroscopy to show that FUS condensates cause partial unfolding of TERRA RNA G-quadruplexes, suggesting phase-separated environments modulate RNA structure.

This study introduces β-sheet breaking proline residues into FUS prion-like domain to prevent aggregation and toxicity while preserving phase separation and function.

This study identifies the glycine-arginine-rich motif of 53BP1 as essential for RNA interactions and phase separation during DNA damage response, showing its role in DNA repair.

This study shows RNA modulates FUS condensate assembly and aggregation through specific molecular interactions, affecting phase separation and aggregate formation.

The paper expands the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation by showing additional residues contribute to these processes.