Shuo-Lin Weng

The paper introduces a computational framework to model pH gradients in biomolecular condensates and shows sequence-dependent pH shifts in FUS and PGL-3.

The paper investigates how condensate material properties affect exopher cargo selection in neurons, finding that gel-like condensates are more efficiently recruited than liquid-like ones.

This study introduces β-sheet breaking proline residues into FUS prion-like domain to prevent aggregation and toxicity while preserving phase separation and function.

This study uses atomistic simulations to analyze the conformational dynamics and interdomain interactions of full-length FUS during phase separation, revealing key electrostatic interactions and domain stability effects.

The paper expands the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation by showing additional residues contribute to these processes.