Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells
Jeffrey L. Platt, Chong Zhao, Jeffrey Chicca, Matthew James Pianko, Joshua Han, Stephanie The, Arvind Rao, Evan T. Keller, Mayara Garcia de Mattos Barbosa, Lwar Naing, Tracy Pasieka-Axenov, Lev Axenov, Simon Schaefer, Evan A. Farkash, Marília Cascalho
This study shows that intracellular C3d enhances immune surveillance by inducing T cell responses against malignant plasma cells while sparing normal cells in a murine model of multiple myeloma.
Proceedings of the National Academy of Sciences · Dec 18, 2024Peer-reviewedImmunology