Author

Lyndsay L. Leach

University of PittsburghORCID 0000-0002-5138-1371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Jeffrey M. GrossiD· 4 shared Fangfang LuiD· 2 shared Ana E. GabrieliD· 1 shared Brian A. LinkiD· 1 shared Dwight K. Romanovicz· 1 shared Edward A. BurtoniD· 1 shared Enhua Shao· 1 shared Kayleigh SlateriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersDevelopmental Biology

Jeffrey M. GrossORCID

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4 papers

Recent·Most cited

Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish

Lyndsay L. Leach, Rebecca G. Gonzalez, Sayuri U. Jayawardena, Jeffrey M. Gross

This study identifies interleukin-34 signaling and mononuclear phagocyte debris clearance as critical for RPE regeneration in zebrafish.

bioRxiv · Jan 10, 2025 · PreprintImmunology

A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium

Fangfang Lu, Lyndsay L. Leach, Jeffrey M. Gross

The paper presents a CRISPR-Cas9-mediated F0 screen in zebrafish to identify genes regulating RPE regeneration, finding eight positive and seven negative regulators, including cldn7b with novel roles in macrophage infiltration and debris clearance.

Scientific Reports · Feb 23, 2023Peer-reviewedDevelopmental Biology

mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish

Fangfang Lu, Lyndsay L. Leach, Jeffrey M. Gross

This study shows that mTOR activity is necessary and sufficient for RPE regeneration in zebrafish, with immune cell interactions playing a key role in this process.

PLoS Genetics · Mar 10, 2022Peer-reviewedDevelopmental Biology

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation

Nicholas J. Hanovice, Lyndsay L. Leach, Kayleigh Slater, Ana E. Gabriel, Dwight K. Romanovicz, Enhua Shao, Ross F. Collery, Edward A. Burton, Kira L. Lathrop, Brian A. Link, Jeffrey M. Gross

This study demonstrates that zebrafish can regenerate a functional RPE monolayer after widespread RPE ablation, with regeneration originating from peripheral RPE cells and requiring Wnt signaling.

PLoS Genetics · Jan 29, 2019Peer-reviewedDevelopmental Biology