Author

Marek Svoboda

Dartmouth CollegeORCID 0000-0002-5166-673XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Giovanni BoscoiD· 4 shared Carly A. BobakiD· 2 shared Felicia D. GoodrumiD· 2 shared Olivia Daigle· 2 shared Pierce LongmireiD· 2 shared Sebastian Zeltzer· 2 shared Bryan W. LuikartiD· 1 shared Hildreth Robert FrostiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

Giovanni BoscoORCID

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4 papers

Recent·Most cited

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity

Pierce Longmire, Sebastian Zeltzer, Kristen Zarrella, Olivia Daigle, Marek Svoboda, Justin M. Reitsma, Scott S. Terhune, Carly A. Bobak, Giovanni Bosco, Felicia D. Goodrum

This paper identifies UL138 as a viral protein that modulates host DNA repair pathways to maintain viral genome integrity during replication.

Nucleic Acids Research · Dec 5, 2025Peer-reviewedMicrobiology

Complex roles for proliferating cell nuclear antigen in human cytomegalovirus replication

Pierce Longmire, Olivia Daigle, Sebastian Zeltzer, Matias Lee, Marek Svoboda, Marco Padilla‐Rodriguez, Carly A. Bobak, Giovanni Bosco, Felicia D. Goodrum

This study investigates the role of PCNA in HCMV replication, finding it restricts virus replication and contributes to genome diversity through separable PCNA-dependent and -independent mechanisms.

bioRxiv · Jan 6, 2025 · PreprintMicrobiology

Internal oligo(dT) priming in bulk and single cell RNA sequencing

Marek Svoboda, Hildreth Robert Frost, Giovanni Bosco

The paper identifies and mitigates the effects of internal oligo(dT) priming in bulk and single cell RNA sequencing, improving gene expression measurement.

NAR Genomics and Bioinformatics · Mar 31, 2022Peer-reviewedGenomics

Single-cell RNA sequencing of conditional Pten knockout neurons in mice

Marek Svoboda, Bryan W. Luikart, Giovanni Bosco

The paper uses scRNA-seq to study gene expression changes in conditional Pten knockout mouse neurons, identifying altered gene expression patterns.

bioRxiv · Mar 17, 2022 · PreprintNeuroscience