Christine Maria Lim

The paper identifies microglial transcriptional programs as predictors of inter-individual variation in neuronal aging using single-nucleus RNA sequencing data from 226 adults.

The paper identifies metabolite-specific failure thresholds in yeast linked to network topology, solubility, and translational control, revealing mechanisms of metabolic toxicity and resilience.

The paper maps the alpha-synuclein proteostasis network in Parkinson's disease, defines a proteostasis activity score, and applies it to drug repurposing and target identification.

This study defines proteostasis signatures across 32 human diseases, revealing disease-specific perturbations, temporal changes, and the impact of smoking on proteostasis.

The paper maps the proteostasis network of membraneless organelles, revealing the role of anabolic components and molecular chaperones in regulating protein conformations.

The paper investigates the connection between Aβ and tau proteostasis networks, identifying HSP90 as a central hub that links their dysregulation in Alzheimer's disease.

The paper identifies Imood as an intrinsically disordered protein with distinct expression patterns in T cells and plasma of OCD patients.

This study shows that downregulating FBXO2 in human iPSC-derived neurons leads to Alzheimer's disease-like features including Aβ aggregation and tau hyperphosphorylation.