Klaus P. Ebmeier

This paper investigates the causal impact of opioid use disorder on brain health outcomes using observational and genetic analyses, finding increased dementia risk associated with both OUD diagnoses and genetic predisposition to OUD.

The paper shows that higher genetic risk for Alzheimer's disease is linked to faster brain volume loss and memory decline in healthy adults.

The paper investigates the effects of short sleep on brain structure and cognitive function, finding that short sleepers without daytime tiredness have larger brain volumes but slightly lower cognitive scores.

The paper investigates how general cognitive ability relates to cortical brain volume changes over time, finding associations with both brain reserve and maintenance mechanisms.

This study evaluates performance metrics in brain-age prediction across datasets, showing variability based on age range, sample size, and age-bias correction.

This study examines the relationship between sleep duration and brain structure using MRI data, finding that 6.8 hours of sleep is associated with the most favorable brain outcomes, with genetic analyses suggesting homeostatic regulation of sleep duration.

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

The paper examines how education and income relate to brain and cognitive differences across European and US cohorts, finding heterogeneous effects and stronger associations in US samples.

This paper harmonises white matter hyperintensity measurements across two neuroimaging datasets by standardising preprocessing and modelling demographic and physiological differences.

This study finds that worse self-reported sleep relates to faster hippocampal microstructural decline in β-amyloid positive adults, independent of genetic risk.

This paper identifies two latent brain structure-cognition associations in aging using longitudinal data from the Whitehall II Study, showing how structural variations predict cognitive decline and maintenance.

The paper predicts brain age using multimodal MRI data from the Whitehall II cohort and links brain aging to cardiovascular risk factors.

This study links a history of childbirths to region-specific brain aging patterns in middle and older-aged women using brain-age prediction methods.

The paper examines the relationship between self-reported sleep parameters and cortical thinning in aging, finding associations with specific brain regions but not with memory decline or amyloid-β accumulation.

This study examines the relationship between mid-life and late life leisure activities and MRI measures of brain structure and functional connectivity in older adults from the UK Biobank.

The paper examines how self-reported sleep relates to hippocampal atrophy across adulthood using data from the Lifebrain consortium and UK Biobank, finding that worse sleep is linked to faster hippocampal volume loss over time.