Sidney B. Cambridge

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice

This study shows that biphasic Npas4 expression suppresses fear memory consolidation and promotes behavioral flexibility in mice by facilitating fear extinction.

Genetic engineering for in vivo optical interrogation of neuronal responses to cell type-specific silencing

This paper describes a genetic engineering approach for cell type-specific silencing and in vivo imaging of neuronal responses.

Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain

The paper identifies acute and lasting molecular, cellular, and behavioral changes in mice after single-dose ethanol intoxication using proteomics and imaging.

Acute ethanol intoxication induces preferred loss of presynaptic boutons devoid of mitochondria in vivo

This study shows that acute ethanol intoxication causes loss of presynaptic boutons without mitochondria in mice, potentially explaining memory impairments.