Dann Turner

Convergent evolution of psilocybin biosynthesis by psychedelic mushrooms

Comparative mushroom genomics and fly-rearing experiments reveal an alternative psilocybin biosynthetic gene cluster in Inocybe corydalina, horizontal transfer of the canonical cluster, and incomplete defense against dipteran larvae.

De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies

This study uses single-cell transcriptomics and germline haplotype assembly to discover antibodies from human blood post-MMR vaccination, showing neutralization of measles virus.

Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for Rapid, Accurate, and Affordable Somatic Mutation Detection

OCEANS improves nanopore sequencing for detecting low VAF somatic mutations with high accuracy and sensitivity in clinical samples.

Nanopore sequencing of DNA concatemers reveals higher-order features of chromatin structure

Pore-C reads multi-way chromatin contacts directly off unamplified Nanopore long reads, recovering Hi-C-scale features while also resolving rearranged cancer alleles and supporting de novo assembly.

Paternally inherited noncoding structural variants contribute to autism

This study identifies rare paternally-inherited structural variants contributing to autism by disrupting noncoding regions and coding genes, with differential parental contributions.

Linear Assembly of a Human Y Centromere

The paper uses nanopore sequencing to assemble and characterize the centromeric region of a human Y chromosome, overcoming challenges posed by repetitive DNA.