Author

Akash Sookdeo

New York Genome Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:perturbation response prediction· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

Neville E. SanjanaiD· 3 shared Wells H. BurrelliD· 2 shared Zharko DaniloskiiD· 2 shared Alejandro Méndez‐MancillaiD· 1 shared Anne Bruun RovsingiD· 1 shared Antonino MontalbanoiD· 1 shared Chia-Yu Kung· 1 shared Chien-Yu Chou· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenomics

Neville E. SanjanaORCID

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3 papers

Recent·Most cited

Rational design of synthetic proteins using a genome-scale CRISPR screen

Wells H. Burrell, Simon J. Mueller, Zharko Daniloski, P. Duffy Doyle, Anne Bruun Rovsing, Christopher James, Max Drabkin, Chien-Yu Chou, Hei Yu Annika So, Lyla Katgara, Akash Sookdeo, Lu Lu, Georges-Ibrahim Cisse, Rachel E Yan, Neville E. Sanjana

The paper designs synthetic proteins for precise gene editing using CRISPR screens and shows improved editing efficiency in various cell types.

bioRxiv · Feb 20, 2026 · PreprintBioengineering

Transcriptome-wide profiling of alternative splicing regulators with CRISPore-seq

Simon Müller, Nathanael Andrews, Rachel Yan, Akash Sookdeo, Wells H. Burrell, Xiaoguang Dai, Priyesh Rughani, Zharko Daniloski, Sissel Juul, Neville E. Sanjana

CRISPore-seq combines CRISPR perturbations with long-read transcriptomics to detect alternative splicing changes, revealing that exon skipping is common and linked to RNA-binding protein perturbations.

bioRxiv · Nov 25, 2025 · PreprintGenomics

Scalable pooled CRISPR screens with single-cell chromatin accessibility profiling

Noa Liscovitch‐Brauer, Antonino Montalbano, Jiale Deng, Alejandro Méndez‐Mancilla, Hans‐Hermann Wessels, Nicholas G. Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan T. Geller, Suma Jaini, Peter Smibert, Neville E. Sanjana

This paper introduces CRISPR-sciATAC, a method linking genetic perturbations to chromatin accessibility in single cells, showing its effectiveness in human and mouse experiments.

Nature Biotechnology · Apr 29, 2021Peer-reviewedGenomics