Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in Cryptococcus neoformans
Kyungyoon Yoo, Somanon Bhattacharya, Natália Kronbauer Oliveira, Nívea Pereira de Sá, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C. Fries
This study identifies mitochondrial metabolic changes in old Cryptococcus neoformans cells that drive fluconazole tolerance through increased ergosterol synthesis and ABC transporter upregulation.
mBio · Aug 13, 2024Peer-reviewedMicrobiology