Jacob Hepkema

The paper uses enhancer scrambling to study a super-enhancer of the OTX2 gene, finding that a single DNase I hypersensitive site predominantly controls its expression.

The paper uses a convolutional neural network to identify regulatory motifs and their cell type-specific importance from single-cell data, explaining 29% of gene expression variance in mouse tissues.

The paper shows that inserting short introns into transgenes improves their expression by reducing cryptic splicing, particularly for the SARS-CoV-2 Spike protein.