Kärt Tomberg

The paper investigates how Cas9-induced large deletions and small indels are regulated, showing their connection through repair mechanisms and locus-specific factors.

The paper shows that inserting short introns into transgenes improves their expression by reducing cryptic splicing, particularly for the SARS-CoV-2 Spike protein.

The paper identifies a de novo mutation in Plcb4 that suppresses thrombosis in mice with Factor V Leiden and tissue factor pathway inhibitor mutations.

This study shows that SEC24D can functionally substitute for SEC24C in mice, as Sec24cc-d/c-d pups survive to term despite embryonic lethality in Sec24c null mice.

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.