POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in mice
Marisa A Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill‐Skoloff, Sol Schulman, Matthew J. Flick, Robert C. Flaumenhaft, Nicola Pozzi
This study evaluates POmAb, an anti-prothrombin antibody, in mice showing it reduces thrombin generation and fibrin formation without excessive bleeding.
Journal of Thrombosis and Haemostasis · Feb 13, 2026Peer-reviewedMolecular Biology