Author

Xuepeng Wei

Guangzhou LaboratoryORCID 0000-0002-6514-7076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Jinsai ShangiD· 2 shared Ronen MarmorsteiniD· 2 shared Zhenglai ZhangiD· 2 shared B Y Xiao· 1 shared Boyu Yin· 1 shared Buwei HuangiD· 1 shared Buyun TianiD· 1 shared David BarteeiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

Jinsai ShangORCID

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Author profile →

4 papers

Recent·Most cited

Mechanism of fatty acid uptake and inhibition in human FATP2

Zhenglai Zhang, Mengqing Zhou, Y Huang, Wencheng Wu, Haizhan Jiao, Minxian Dai, Taizhen Liang, Jiayue Wen, Ziqi Cheng, Xiancai Ma, Jiao Yuan, Hongli Hu, Jinsai Shang, Ronen Marmorstein, Xuepeng Wei

This paper presents cryo-EM structures of human FATP2, revealing its fatty acid uptake mechanism and drug inhibition strategies.

bioRxiv · Jul 10, 2026 · PreprintBiophysics

Structural assemblies for an RNA world

Yukun Ren, Zhenglai Zhang, Ke Chen, Mengxiao Li, Yuting Xie, Tiantian Bai, Buwei Huang, B Y Xiao, Éric Westhof, David M.J. Lilley, Jia Wang, Zhichao Miao, Xuepeng Wei, L Huang

The paper shows short RNAs can form complex structures like icosahedrons and filaments, expanding the known RNA quaternary structures and supporting RNA-based self-assembly in an RNA world.

bioRxiv · Jul 1, 2026 · PreprintEvolutionary Biology

Molecular Basis for RNA Cytidine Acetylation by NAT10

Mingyang Zhou, Supuni Thalalla Gamage, Khoa A. Tran, David Bartee, Xuepeng Wei, Boyu Yin, Shelley L. Berger, Jordan L. Meier, Ronen Marmorstein

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

Nature Communications · Jun 19, 2026Peer-reviewedBiophysics

Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection

Xubing Long, Rongrong Chen, Rong Bai, Buyun Tian, Yu Cao, K Chen, Fu‐Yu Li, Yiliang Wang, Yongjie Tang, Qi Yang, Liping Ma, Fan Wang, Maoge Zhou, Xianjie Qiu, Yongzhi Lu, , Zonghong Li

This study identifies HGS as a host factor critical for coronavirus infection and discovers RTB as a broad-spectrum antiviral by disrupting HGS-M protein interaction.

Journal of Clinical Investigation · Dec 16, 2025Peer-reviewedMicrobiology