Naibedya Dutta

Expression of tardigrade intrinsically disordered proteins in C. elegans reveals variable effects on aging and stress

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

Form and function of actin impacts actin health and aging.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

Epoxyazadiradione ameliorates Parkinson's disease by upregulating heat shock factor 1 and protein degradation pathways in mice.

This paper identifies Epoxyazadiradione as a compound that improves Parkinson's disease symptoms in mice by enhancing heat shock factor 1 and protein degradation pathways without affecting redox balance.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans

This study uses RNA-sequencing to analyze transcriptomic changes in C. elegans under different mitochondrial stressors that activate UPRmt, aiming to determine if specific transcriptomic changes correlate with longevity.

Cross comparison of imaging strategies of mitochondria in C. elegans during aging.

This study compares mitochondrial imaging strategies in C. elegans during aging, evaluating transgenic constructs for mitochondrial morphology analysis.

HSF1 Activator Azadiradione Ameliorates Parkinson Disease and Extends Lifespan in Preclinical Models: Analysis of Underlying Molecular Mechanism

This study shows that azadiradione enhances protein quality control mechanisms and alleviates Parkinson's disease symptoms in preclinical models.

Glial-derived mitochondrial signals impact neuronal proteostasis and aging.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.