Charles A. O’Brien

TENGU improves spatial transcriptomics by using transcript-signal density for cell segmentation and simulation, enhancing accuracy in complex tissues.

This study deletes Scarb1 in osteoblast progenitors and myeloid cells and finds no effect on bone mass.

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

This study creates a harmonized atlas of murine bone-associated cells using single-cell RNA sequencing to clarify cell type designations and identify osteoblast progenitors.