This study investigates PARP16's role in ovarian cancer by showing that inhibiting it with DB008 disrupts ribosome MARylation, impairs protein homeostasis, and reduces tumor growth.

Journal of Biological Chemistry · Sep 8, 2026Peer-reviewedCancer Biology

RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells

Alexandra N. Spirtos, Marwa W. Aljardali, Sridevi Challa, Sneh Koul, Jayanthi Sivasothy Lea, W. Lee Kraus, Cristel V. Camacho

This study shows that RBN-2397, a PARP7 inhibitor, reduces ovarian cancer cell proliferation and migration, and synergizes with paclitaxel to enhance these effects.

bioRxiv · Aug 20, 2024 · PreprintCancer Biology

Development and Characterization of PAR-Trackers: New Tools for Detecting Poly(ADP-ribose) In Vitro and In Vivo

Sridevi Challa, Keun W. Ryu, Amy L. Whitaker, Jonathan C. Abshier, Cristel V. Camacho, W. Lee Kraus

The paper develops and characterizes PAR-Trackers, new tools for detecting poly(ADP-ribose) in vitro and in vivo, showing improved sensitivity and spatial-temporal resolution.

eLife · Mar 23, 2022Peer-reviewedSynthetic Biology