Morgan Dasovich

This study investigates PARP16's role in ovarian cancer by showing that inhibiting it with DB008 disrupts ribosome MARylation, impairs protein homeostasis, and reduces tumor growth.

The paper maps PARP1 ADP-ribosylated proteomes in breast cancer subtypes, identifying subtype-specific modifications and their functional implications.

This study identifies PARP7 as a key regulator of C/EBPβ-dependent adipogenesis and shows it senses nuclear NAD+ levels to control gene expression and lipid production in mammary glands.

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

The paper identifies a deficient PAR response in Huntington disease patients, suggesting a potential therapeutic target for early intervention.

The paper introduces a PAR photoaffinity probe to identify PAR-binding proteins, revealing novel binders and demonstrating length-selective PAR binding.