Charles A. R. Cotton

This paper presents a computational workflow for designing and testing E. coli metabolic sensors that detect glyoxylate and glycolate across a wide concentration range, with applications in bioengineering and environmental monitoring.

This study replaces the Calvin cycle in Cupriavidus necator with a synthetic reductive glycine pathway to improve formate assimilation and growth.

The paper reveals how CP12 regulates the Calvin cycle by structurally pre-ordering itself before binding PRK and influencing GAPDH activity based on redox state and NAD availability.