Author

Matthew L. Rook

University of Rochester MedicineORCID 0000-0002-5332-7678Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:chicken / avian· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David M. MacLeaniD· 2 shared Abby Williamson· 1 shared John D. LueckiD· 1 shared Maria MusgaardiD· 1 shared Rutambhara PurohitiD· 1 shared Tyler A. CouchiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

David M. MacLeanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsBiophysical JournalPeer-reviewedSep 3, 2024

Proline substitutions in the ASIC1 β11-12 linker slow desensitization

Rutambhara Purohit, Tyler A. Couch, Matthew L. Rook, David M. MacLean

This study shows that proline substitutions in the ASIC1 β11-12 linker significantly slow desensitization, with minimal effects on activation and ion selectivity.

2 citations

chicken / avianelectrophysiology

𝕏 PostBluesky

NeuroscienceeLifePeer-reviewedFeb 7, 2020

β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery

Matthew L. Rook, Abby Williamson, John D. Lueck…·David M. MacLean

The paper investigates the role of β11-12 linker isomerization in ASIC desensitization and recovery using electrophysiology, simulations, and cross-linking.

52 citations

experimental assay

𝕏 PostBluesky