Feng He

Dcp2 C-terminal Cis-Binding Elements Control Selective Targeting of the Decapping Enzyme by Forming Distinct Decapping Complexes

The paper identifies cis-binding elements in Dcp2 that form distinct decapping complexes, controlling mRNA targeting specificity in yeast.

Progressive polysomal association of Upf1, Upf2, and Upf3 as ribosomes traverse mRNA coding regions

The paper investigates the timing and nature of Upf1, Upf2, and Upf3 ribosome association during NMD, revealing progressive polysome association and an early Upf1:80S complex.

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae

The paper investigates stop codon readthrough in yeast using ribosome profiling and bioinformatics to identify mRNA features influencing termination efficiency.

Nonsense suppression position effect implicates poly(A)-binding protein in the regulation of translation termination

The paper investigates how the position of nonsense codons affects readthrough efficiency in yeast, showing that poly(A)-binding protein regulates translation termination.

General decapping activators target different subsets of inefficiently translated mRNAs

The paper identifies that decapping activators target specific subsets of inefficiently translated mRNAs and reveal the role of the Dcp2 C-terminal domain in both positive and negative regulation.