Allan Jacobson

This study identifies the ribosome as the activator of angiogenin, revealing how it enhances tRNA cleavage efficiency and ensures substrate specificity through structural rearrangements.

This study examines the effects of PAB1 deletion in yeast on translation initiation, termination, and mRNA decay using RNA-Seq, Ribo-Seq, and mass spectrometry, revealing both direct and indirect consequences.

The paper identifies cis-binding elements in Dcp2 that form distinct decapping complexes, controlling mRNA targeting specificity in yeast.

The paper investigates the timing and nature of Upf1, Upf2, and Upf3 ribosome association during NMD, revealing progressive polysome association and an early Upf1:80S complex.

The paper investigates stop codon readthrough in yeast using ribosome profiling and bioinformatics to identify mRNA features influencing termination efficiency.

The paper investigates how the position of nonsense codons affects readthrough efficiency in yeast, showing that poly(A)-binding protein regulates translation termination.

The paper identifies that decapping activators target specific subsets of inefficiently translated mRNAs and reveal the role of the Dcp2 C-terminal domain in both positive and negative regulation.