Author
University of CologneORCID 0000-0001-7937-3974Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Miguel da Silva Padilha, Seda Koyuncu, Evangeline Chabanis…·Irina Dudanova
Anle138b reduces mHTT aggregates and improves disease phenotypes in HD cell and mouse models.
Ernesto Llamas, Thomas Kell, Maurice Koenig…·Alga Zuccaro
This paper identifies prion-like domains (PrLDs) as noncanonical plastid-targeting elements in PEPSI effectors and shows PEPSI6 modulates DXR during root symbiosis.
Stephanie Fernandes, Jiyoung Pan, Diana S. Terziyska…·Constantinos Demetriades
This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.
Xuexin Li, Ivó H. Hernández, Seda Koyuncu…·Óscar Fernández-Capetillo
The paper identifies clofazimine as a drug that reduces polyQ toxicity by activating PPARγ, improving mitochondrial function in models of polyQ diseases.
Kerstin Voelkl, Sara Gutiérrez-Ángel, Sophie Keeling…·Irina Dudanova
This study shows that hepatoma-derived growth factor (HDGF) has neuroprotective effects in Huntington's disease models by reducing mutant Huntingtin toxicity and aggregation.