Vishruth Mullapudi

This study identifies DnaJC7 as a specific regulator of tau seeding through its interaction with Hsp70, showing that its protective activity depends on the J domain and substrate binding site.

The paper uses an in silico alanine scan method to identify energetically important interactions in tau amyloid fibrils and classifies structures using machine learning.

The paper shows that seed-competent tau monomer (Ms) forms before insoluble fibrils in PS19 tauopathy mice, initiating pathology in a phosphorylation-independent manner.