An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism
Laxmikant G. Gadhe, Binh An Nguyen, María del Carmen Fernández‐Ramírez, Katerina Konstantoulea, Macy L. Lozen, Harichandra D. Tagad, Aydé Mendoza‐Oliva, Jaime Vaquer‐Alicea, Marc I. Diamond, Lorena Saelices, Nikolaos N. Louros
This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.
bioRxiv · Sep 8, 2026 · PreprintBiophysics