Steffy B. Manjila

Neuronal and vascular genome-maintenance states organize opposing multicellular architectures in the aging brain

The paper maps DNA damage response states in aging mouse brains, revealing opposing neuronal and vascular spatial patterns linked to genome maintenance.

Scale-Aware Compositional Inference Improves Reproducibility and Uncovers Convergent Aging Programs in Spatial Transcriptomics

This paper introduces a scale-aware framework for spatial differential expression that improves reproducibility and identifies convergent aging programs in aged mouse brains.

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

This study maps the connectivity and function of the dorsal endopiriform nucleus in mice, revealing its role in olfaction and response to novel stimuli through Oxtr-expressing neurons.

Developmental Mouse Brain Common Coordinate Framework

The paper develops a 3D developmental common coordinate framework (DevCCF) for mouse brains across multiple developmental stages to enable data integration and analysis of brain development.

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

This study identifies age-related changes in cerebrovascular structure and function in the mouse brain, including reduced vascular length and increased tortuosity in specific regions.

Wiring diagram of the oxytocin system in the mouse brain

This study maps the whole-brain connectivity of oxytocin neurons in mice, revealing distinct roles of paraventricular and supraoptic OT neurons in circuit-specific functions.