Hoon Kim

This study identifies glial progenitor cells as the cell-of-origin for IDH-mutant gliomas by analyzing patient tissues and mouse models.

AmpliconSuite identifies focal amplifications in cancer genomes, showing ecDNA has higher copy numbers and stronger oncogene enrichment compared to other amplification types.

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.

The paper analyzes tumor-intrinsic gene expression subtypes in IDH wild type glioblastomas and their association with immune microenvironment changes during recurrence.