Girolamo Giudice

Differential regulation of the proteome and phosphosproteome along the dorso-ventral axis of the early Drosophila embryo

The paper investigates proteome and phosphoproteome changes along the dorso-ventral axis of Drosophila embryos, revealing differential regulation and functional roles of proteins and phosphorylation events.

phuEGO: A network-based method to reconstruct active signalling pathways from phosphoproteomics datasets

phuEGO reconstructs active signalling pathways from phosphoproteomics data by combining network propagation and decomposition to improve functional interpretation.

In silico network-based screening reveals candidates for endothelial dysfunction therapy

The paper identifies 17 candidate genes for endothelial dysfunction therapy using computational network analysis and in silico perturbation, with one target showing anti-inflammatory and antioxidant effects.

Identification of phenotype-specific networks from paired gene expression-cell shape imaging data

The paper integrates gene expression and cell shape imaging data to identify phenotype-specific gene networks and signaling pathways involved in breast cancer cell morphology.

Proteome-wide inference of protein kinase regulatory circuits

The paper predicts human kinase-kinase regulatory relationships and their effects using data-driven methods, revealing a sparse but denser network than typically considered.