Pedro R. Cutillas

Neuro-mimetic reprogramming and epigenetic unlocking drive lung cancer stem cell adaptation to the brain microenvironment

This study shows lung cancer stem cells adapt to the brain microenvironment through neuro-mimetic reprogramming and epigenetic changes, enabling metastasis.

Greatwall Kinase regulates Acute Myeloid Leukaemia Cell Division through a Non-Canonical Mechanism

This study shows Greatwall kinase regulates AML cell division through a non-canonical pathway distinct from its role in solid tumors.

β3-Integrin controls pericyte metabolic states and shapes tumour-stromal metabolic crosstalk in breast cancer

This study identifies two β3-integrin-dependent metabolic states in pericytes and shows their impact on tumour-stromal metabolic interactions in breast cancer.

DUSP6 is transcriptionally upregulated by activated ALK and cooperates with ALK signaling to reduce lorlatinib sensitivity in neuroblastoma cells

This study identifies DUSP6 as a novel effector of ALK signaling in neuroblastoma, showing it enhances ALK-driven proliferation and reduces sensitivity to ALK inhibitors.

Quantitative phosphoproteomics uncovers the signalling dynamics of hallucinogenic psychedelics

This study uses quantitative phosphoproteomics to show that hallucinogenic psychedelics induce distinct global phosphorylation patterns compared to non-hallucinogenic analogues, with functional relevance to glycolytic metabolism.

An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Understanding the Sources of Performance in Deep Drug Response Models Reveals Insights and Improvements

The paper evaluates deep learning models for drug response prediction, finds transcriptomics data drives performance, and introduces new models that learn chemical features.

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors

High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing

This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.

Maternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells

This study identifies translational dysregulation and MAP2 phosphorylation differences in neural stem cells from offspring exposed to maternal immune activation.

RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

The paper identifies two distinct subgroups of KMT2A-rearranged AML using phosphoproteomics and shows different drug response profiles.

Community detection in empirical kinase networks identifies new members of signaling pathways

The paper applies community detection to kinase networks derived from phosphoproteomics data to identify new signaling pathway components, finding TTK as a potential member of PI3K/AKT/mTOR signaling.

Proteome-wide inference of protein kinase regulatory circuits

The paper predicts human kinase-kinase regulatory relationships and their effects using data-driven methods, revealing a sparse but denser network than typically considered.

Spatial Regulation of Polo-like Kinase Activity during C. elegans Meiosis by the Nucleoplasmic HAL-2/HAL-3 Complex

This study identifies the HAL-2/HAL-3 complex as essential for regulating Polo-like kinase activity during C. elegans meiosis, ensuring proper homolog pairing and synaptonemal complex assembly.