Yun Hua Fang

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.

This study identifies desert hedgehog (DHH) as a resilience factor that prevents atherosclerosis by inhibiting PAI-1 signaling and endothelial mesenchymal transition.

This paper develops a composite biomaterial combining polyelectrolyte complex micelles with hyaluronic acid gels to deliver miR-92a inhibitors, enhancing angiogenesis and accelerating wound healing in diabetic mice.

This paper develops a targeted IL-10 therapy by fusing it with an LDL-binding antibody fragment, showing reduced vascular inflammation in atherosclerotic mice.

This study analyzes 180 metagenome-assembled genomes of the WOR-3 phylum to reveal four subgroups with distinct metabolic capabilities, including carbon fixation via archaeal form III RuBisCO and versatile sulfur and nitrogen metabolism.

This paper develops a modular nanoparticle platform for targeted mRNA delivery to inflamed endothelial cells, showing efficacy in treating ARDS and atherosclerosis by restoring disease-related gene pathways.

The paper identifies a CAD risk SNP rs880890 in an endothelial enhancer that reduces CALCRL expression by impairing HSF binding under shear stress.

The paper identifies 17 candidate genes for endothelial dysfunction therapy using computational network analysis and in silico perturbation, with one target showing anti-inflammatory and antioxidant effects.

This study compares immune responses and metabolism in SARS-CoV-2 and HIV-1 infections using single-cell transcriptomics, identifying shared and distinct features in 94,442 PBMCs from 16 patients.

This study shows that Decitabine can reactivate FoxM1-dependent vascular repair in aged mice, improving survival after sepsis and suggesting potential treatment for elderly ARDS and COVID-19 patients.

This study identifies a genetic variant at 1p32.2 that regulates endothelial responses to hemodynamics by modulating an enhancer region in vascular endothelium.