Francesca Bottanelli

This study investigates the role of AP-1 clathrin adaptor in recycling trans-Golgi network proteins, showing it maintains these proteins in the Golgi during maturation.

This study identifies ARF-1 as a regulator of cargo sorting at FERARI-dependent endosomal recycling hubs through its cycling between active and inactive states.

This study investigates the role of GGAs in AP-1-dependent trafficking using CRISPR-Cas9 and live-cell imaging, finding GGAs modulate bi-directional trafficking by preventing AP-1 cargo retrieval.

This study shows that T cell protrusions enable rapid and localized initiation of CAR signaling by facilitating dynamic rearrangement of key signaling molecules.

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.