Filip Kovačić

This study identifies three pharmaceuticals that inhibit Pseudomonas aeruginosa phospholipase A, showing they reduce bacterial growth and enhance antibiotic efficacy.

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

This study investigates how Pseudomonas aeruginosa phospholipase A (PlaF) affects biofilm formation and virulence by altering membrane phospholipid composition and regulating multiple pathways.

This paper identifies PlaF, a bacterial phospholipase A1 involved in GPL remodeling, and characterizes its structure and mechanism of dimerization-mediated inactivation.

The paper predicts biochemical functions and potential drug targets for 2103 hypothetical proteins in Pseudomonas aeruginosa using homology modelling, identifying 11 promising targets for antibiotic development.