Oliver Beckstein

This study shows that prestin's conformational changes during electromechanical transduction resemble a transport transition in pendrin, with shared structural and functional properties.

The paper investigates the structural differences between human and bacterial SLC10 family transporters, revealing that a pore is not common to the family and highlighting lipid interactions in bile acid transport.

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

The paper uses Bayesian nonparametric methods to analyze residence times of cholesterol interactions with GPCRs in MD simulations, revealing kinetic rates and molecular events.

KDA is a Python library that generates symbolic expressions for steady-state observables of biochemical systems, demonstrating its use on transporters with varying states and kinetic rates.

This study shows chloride binding does not affect very high-frequency nonlinear capacitance in mouse outer hair cells, suggesting mechanical loads, not anion interactions, govern high-frequency prestin function.