Katherine B. McCullough

Lactational transfer of synthetic oxytocin and sex-specific suppression of neurodevelopmental risk gene networks in the rat prefrontal cortex

This study shows that synthetic oxytocin administered during postpartum hemorrhage prophylaxis in rats transfers via lactation and specifically suppresses neurodevelopmental risk gene networks in male offspring prefrontal cortex.

A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice.

This study examines the molecular and behavioral effects of MYT1L haploinsufficiency in mice, finding region-specific hypothalamic disruptions and sex-specific behavioral stability.

A simple action reduces high fat diet intake and obesity in mice

This study shows that requiring mice to perform a simple action to access high-fat diet reduces intake and prevents obesity, suggesting that easy access promotes overeating.

Chromosomal and gonadal sex have differing effects on social motivation in mice

This study investigates how chromosomal and gonadal sex influence social motivation in mice, finding that gonadal sex primarily affects behavior while chromosomal sex interacts with genetic mutations to alter social behavior.

Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits

This study examines how different DNMT3A mutations cause varied behavioral, epigenetic, and transcriptional issues in neurodevelopmental disorders.

Perinatal Oxycodone Exposure Causes Long Term Sex-Dependent Changes in Sensory and Reward Processing in Adult Mice

This study compares long-term effects of in utero versus continued postnatal oxycodone exposure in mice, finding sex-dependent changes in sensory and reward processing but no major behavioral deficits.

A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation

This paper develops a MYT1L syndrome mouse model that recapitulates human phenotypes, revealing disrupted brain development and neuronal maturation as underlying mechanisms.

Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice

This study examines the effects of in utero and postnatal oxycodone exposure on mouse behavior and development, finding sex-dependent weight changes, altered vocalizations, and sensorimotor delays.

Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences.

This study identifies genomic binding sites of Gtf2i and Gtf2ird1 in the developing brain and assesses their combined effects on transcription and behavior in knockout mice.

Maternal SSRI treatment during offspring development results in long-term behavioral, cellular, and neuroimaging disruptions

This study shows that maternal SSRI exposure during offspring development causes long-term behavioral, cellular, and neuroimaging disruptions, suggesting a direct role in ASD risk.