Author

Kevin K. Noguchi

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Joseph D. DoughertyiD· 4 shared Jiayang CheniD· 3 shared Nicole A. Fuhler· 3 shared Susan E. MaloneyiD· 2 shared Allen YeniD· 1 shared Alyssa EricksoniD· 1 shared Audrey McAlindeniD· 1 shared Austin B. LawrenceiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Joseph D. DoughertyORCID

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4 papers

Recent·Most cited

A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the Myt1l gene.

Nicole A. Fuhler, Cory Palmer, Gianna Tunzi, Lilly Tian, Maya Fotedar, Rebecca Chase, Ramachandran Prakasam, Susan E. Maloney, C. Eric Neblock, Jiayang Chen, Kristen L. Kroll, Joseph D. Dougherty, Kevin K. Noguchi

The paper shows a single binge ethanol exposure rapidly increases apoptosis in early adolescent and adult mice, with Myt1l haploinsufficiency modulating this effect across developmental stages.

bioRxiv · Jun 27, 2025 · PreprintNeuroscience

MYT1L deficiency impairs excitatory neuron trajectory during cortical development

Allen Yen, Simona Sarafinovska, Xuhua Chen, Dominic D. Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington‐Lopez, Yizhe Wu, Jiayang Chen, Zipeng Alex Li, Kevin K. Noguchi, Robi David Mitra, Joseph D. Dougherty

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

Nature Communications · Nov 27, 2024Peer-reviewedNeuroscience

Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits

Diana C. Beard, Xiyun Zhang, Dennis Y. Wu, Jenna R. Martin, Alyssa Erickson, Jane-Valeriane K. Boua, Nicole Hamagami, Raylynn G. Swift, Katherine B. McCullough, Xia Ge, Austin Bell‐Hensley, Hongjun Zheng, Cory W. Palmer, Nicole A. Fuhler, Austin B. Lawrence, , Harrison W. Gabel

This study examines how different DNMT3A mutations cause varied behavioral, epigenetic, and transcriptional issues in neurodevelopmental disorders.

Cell Reports · Nov 1, 2023Peer-reviewedNeuroscience

MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain

Jiayang Chen, Nicole A. Fuhler, Kevin K. Noguchi, Joseph D. Dougherty

The paper investigates MYT1L's role in suppressing earlier neuronal development programs in the adult mouse brain, showing it regulates gene expression and chromatin structure in cortical neurons.

bioRxiv · Oct 17, 2022Neuroscience