Federico Agostini

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

The paper investigates somatic recombination of Alu and L1 repeat elements in human genomes, finding tissue-specific patterns and links to neurodegenerative diseases.

The paper studies dehydrin genes in Brachypodium species, identifying their genomic organization, expression patterns, and functional roles in drought tolerance across different ecotypes.

The paper identifies that most intergenic RNA originates from fuzzy transcription of known genes, with a smaller portion from long non-coding RNA loci, and characterizes their transcriptional features and degradation patterns.

RADICL-seq maps genome-wide RNA-chromatin interactions in intact nuclei, revealing general and cell type-specific patterns of transcript occupancy and the role of transcription in chromatin structure.

The paper shows that LINE repeat sequences recruit RNA-binding proteins to repress splicing and 3' end processing in introns, contributing to lineage-specific RNA processing in mammals.