Giovanni Pascarella

The human RNA-DNA interactome is cell type-specific and dynamic

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

Ku limits aberrant mRNA splicing promoted by intronic antisense Alu elements

The paper shows Ku prevents aberrant mRNA splicing caused by intronic antisense Alu elements, which affects RNA metabolism and cell viability.

Nanopore Long-Read Sequencing Unveils Genomic Disruptions in Alzheimer's Disease

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

Challenges in Detecting Somatic Recombination of Repeat Elements: Insights from Short and Long Read Datasets

This study identifies technical challenges in detecting somatic recombination of repeat elements using short and long read datasets and highlights PCR-induced artifacts.

The piRNA pathway sustains adult neurogenesis by repressing protein synthesis and cellular senescence

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.

Recombination of repeat elements generates somatic complexity in human genomes.

The paper investigates somatic recombination of Alu and L1 repeat elements in human genomes, finding tissue-specific patterns and links to neurodegenerative diseases.

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

RADICL-seq maps genome-wide RNA-chromatin interactions in intact nuclei, revealing general and cell type-specific patterns of transcript occupancy and the role of transcription in chromatin structure.