TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral Yersinia infection
Stefan T. Peterson, Katherine G. Dailey, Karthik Hullahalli, Daniel Sorobetea, Rina Matsuda, Jaydeen Sewell, Winslow Yost, Rosemary O’Neill, Suhas Bobba, Nicolai Apenes, Matthew E. Sherman, George I. Balazs, Charles‐Antoine Assenmacher, Arin Cox, Matthew R. Lanza, , Igor E. Brodsky
This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.
mBio · Sep 9, 2025Peer-reviewedMicrobiology