Author

Claudia E. Leonard

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Binkai ChiiD· 2 shared Christina L. ParaggioiD· 2 shared Jiuchun ZhangiD· 2 shared Mahtab Dastpak· 2 shared Robin Reed· 2 shared Erin Frances Cohn· 1 shared George Q. DaleyiD· 1 shared Hyunmin KimiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Binkai ChiORCID

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Author profile →

2 papers

Recent·Most cited

Three ALS genes regulate expression of the MHC class II antigen presentation pathway

Binkai Chi, Muhammet M. Öztürk, Christina L. Paraggio, Claudia E. Leonard, Maria E. Sanita, Mahtab Dastpak, Jeremy D. O’Connell, Jordan A. Coady, Jiuchun Zhang, Steven P. Gygi, Rodrigo Lopez-Gonzalez, Robin Reed

The paper shows that ALS genes FUS, TAF15, and MATR3 regulate the MHC II antigen presentation pathway by downregulating HLA-DR and CD74 through loss of CIITA, with implications for immune system failure in ALS.

bioRxiv · May 11, 2022 · PreprintMolecular Biology

Chemokine Receptor 1 and its associated immune pathway are downregulated in SF3B1MT blood and non-blood cancers

Mahtab Dastpak, Hyunmin Kim, Christina L. Paraggio, Claudia E. Leonard, Shanye Yin, Binkai Chi, Kelsey W. Nassar, R. Grant Rowe, Zhonggang Hou, Jiuchun Zhang, Erin Frances Cohn, Na Young Yang, William Marion, Yosra Zhang, George Q. Daley, Robin Reed

The paper identifies downregulation of the CCR1 immune pathway in SF3B1-mutated cancers and links it to potential therapeutic targets.

bioRxiv · Mar 31, 2022 · PreprintMolecular Biology