Roger Stupp

This study shows that preoperative temozolomide exposure in recurrent glioblastoma leads to inflammatory-repair remodeling and a ROCK-linked therapeutic vulnerability, which can be targeted by fasudil.

This study shows that ultrasound-mediated BBB modulation alone does not generate effective CNS immunity, but combining it with systemic immune activation enhances T-cell responses and improves immunotherapy efficacy.

The paper develops and validates a CNS-specific library and analysis platform using the COMET(TM) system for high-dimensional proteomic multiplex imaging of the central nervous system.