Author

Yasuhito Nannya

Kyoto UniversityORCID 0000-0002-6526-0992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Seishi OgawaiD· 3 shared Akifumi Takaori‐KondoiD· 2 shared Eva Hellström-Lindberg· 2 shared Maria CreignouiD· 2 shared Martin JädersteniD· 2 shared Ryunosuke SaikiiD· 2 shared Senji KasaharaiD· 2 shared Takayuki IshikawaiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

Seishi OgawaORCID

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3 papers

Recent·Most cited

RNA splicing factor mutations drive myeloid neoplasm oncogenesis through protein complex poisoning

Pedro Luís Moura, Rui Mamede Branca, Yaroslav Kaminskiy, Ioannis Siavelis, Kovi R Shrung, Sophia Hofmann, Christina Maria Perraki, Alexandra Argyriou, Sadaf Fazeli, Masahiro M Nakagawa, Teresa Mortera Blanco, Steffen Boettcher, Caroline Kubaczka, Thorsten M. Schlaeger, Maria Creignou, , Eva Hellström-Lindberg

This study identifies how RNA splicing factor mutations drive myeloid neoplasm by disrupting proteomic networks through mis-splicing, validated via single-cell transcriptomics and proteomics.

bioRxiv · Sep 30, 2026 · PreprintCancer Biology

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukemia

Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzén, Bénédicte Piauger, Stefan Deneberg, Martin Jädersten, Vladimir Lazarević, Jörg Cammenga, Anna Robelius, Lovisa Wennström, Emma Ölander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, , Seishi Ogawa

This study identifies 16 AML subgroups based on chromatin accessibility profiles using ATAC-seq in 1,563 cases, revealing epigenetic heterogeneity and its clinical and therapeutic implications.

bioRxiv · May 24, 2026 · PreprintCancer Biology

Implications of TP53 Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes

Elsa Bernard, Yasuhito Nannya, Robert Paul Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan Santiago Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max Fine Levine, Juan E. Arango, Yangyu Zhou, Francesc Gessé Solé, Catherine A. Cargo, , Elli Papaemmanuil

The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.

Nature Medicine · Aug 3, 2020Peer-reviewedGenomics