Author

Zachary J. Frangos

National Institute on Drug AbuseORCID 0000-0002-5499-4050Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Megan L. O’MaraiD· 2 shared Robert J. VandenbergiD· 2 shared Ryan Cantwell ChateriD· 2 shared Ada QuinniD· 1 shared Anna E. TischeriD· 1 shared Azadeh ShahsavariD· 1 shared Billy J. Williams‐NoonaniD· 1 shared Christopher L. CioffiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Megan L. O’MaraORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects

Ryan Cantwell Chater, Julian Peiser-Oliver, Tanmay K. Pati, Ada Quinn, Irina Lotsaris, Zachary J. Frangos, Kristen E. Anderson, Anna E. Tischer, Billy J. Williams‐Noonan, Karin R. Aubrey, Megan L. O’Mara, Michael Michaelides, Sarasa A. Mohammadi, Christopher L. Cioffi, Robert J. Vandenberg, Azadeh Shahsavar

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

bioRxiv · Apr 21, 2025 · PreprintNeuroscience

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

Zachary J. Frangos, Katie A. Wilson, Heather M. Aitken, Ryan Cantwell Chater, Robert J. Vandenberg, Megan L. O’Mara

This study shows how membrane cholesterol modulates GlyT2 function and lipid inhibition, with implications for developing new analgesics.

Life Science Alliance · Jan 23, 2023Peer-reviewedNeuroscience