Megan L. O’Mara

Structural basis of drug efflux by the staphylococcal efflux pump QacA

This study reports crystal structures of the QacA efflux pump in different conformational states, revealing structural dynamics and mechanisms of multidrug transport and extrusion.

A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

This study shows how membrane cholesterol modulates GlyT2 function and lipid inhibition, with implications for developing new analgesics.

Pore structure controls stability and molecular flux in engineered protein cages

This study investigates how pore structure affects stability and molecular flux in engineered protein cages through design, structural analysis, and simulations.