A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects
Ryan Cantwell Chater, Julian Peiser-Oliver, Tanmay K. Pati, Ada Quinn, Irina Lotsaris, Zachary J. Frangos, Kristen E. Anderson, Anna E. Tischer, Billy J. Williams‐Noonan, Karin R. Aubrey, Megan L. O’Mara, Michael Michaelides, Sarasa A. Mohammadi, Christopher L. Cioffi, Robert J. Vandenberg, Azadeh Shahsavar
This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.
bioRxiv · Apr 21, 2025 · PreprintNeuroscience