David A. Scheiblin

This study identifies E-cadherin/YAP-dependent pyruvate carboxylase expression as a metabolic driver of breast cancer progression and metastasis, with therapeutic implications for epithelial TNBC.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

SPAC provides a scalable platform for end-to-end single-cell spatial analysis of multiplexed tissue imaging data, enabling efficient processing and visualization of large datasets.