Author

George Zaki

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-2740-3307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Abigail Wong-RolleiD· 1 shared Arya J. Bahrami· 1 shared Chen Ning ZhaoiD· 1 shared Christopher Simon HouriganiD· 1 shared David A. ScheibliniD· 1 shared David A. WinkiD· 1 shared Eddie Martin· 1 shared Edward C. SchromiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Abigail Wong-RolleORCID

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2 papers

Recent·Most cited

Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML

Gege Gui, Molly A. Bingham, Julius R. Herzog, Abigail Wong-Rolle, Laura Williams Dillon, Meghali Goswami, Eddie Martin, Jason Reeves, Sean T. Kim, Arya J. Bahrami, Hermann Franz Degenhardt, George Zaki, Prajan Divakar, Edward C. Schrom, Katherine R. Calvo, , Chen Ning Zhao

CosMx spatial transcriptomics of bone marrow from 6 refractory/relapsed AML patients shows CD14+ monocytes rising in leukemia-cell neighborhoods after pembrolizumab in responders, dendritic cells in nonresponders.

Science Advances · Jul 9, 2025Peer-reviewedCancer Biology✦ In-depth digest

SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

Fang Liu, Rui He, Thomas Sheeley, David A. Scheiblin, Stephen Lockett, Lisa A. Ridnour, David A. Wink, Mark Jensen, Janelle Cortner, George Zaki

SPAC provides a scalable platform for end-to-end single-cell spatial analysis of multiplexed tissue imaging data, enabling efficient processing and visualization of large datasets.

bioRxiv · Apr 2, 2025 · PreprintBioinformatics