Stephen Lockett

Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP-dependent pyruvate carboxylase expression

This study identifies E-cadherin/YAP-dependent pyruvate carboxylase expression as a metabolic driver of breast cancer progression and metastasis, with therapeutic implications for epithelial TNBC.

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

SPAC provides a scalable platform for end-to-end single-cell spatial analysis of multiplexed tissue imaging data, enabling efficient processing and visualization of large datasets.