ImmunologyJournal of Clinical InvestigationPeer-reviewed
Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation
Kerstin Dürholz, Leona Ehnes, Mathias Linnerbauer…·Mario M. Zaiss
The paper identifies gut microbiota-derived histamine as a factor enabling the CNS to suppress peripheral inflammation in RA by activating H3R in the intestine and modulating microglia.